ALS

Amyotrophic Lateral Sclerosis (ALS), is a devastating neurodegenerative disorder, overlapping with Fronto-temporal Dementia (FTD), and is part of a series of syndromes defined as Motor Neuron Diseases (MND) that is characterized by the progressive loss of motor neurons in the brain and spinal cord[1]. The exact pathology is still unclear, but mechanisms such as mitochondrial dysfunction, oxidative stress, inflammation, and glutamate overload are thought to contribute to neuronal loss[2]. ALS is classified based on the initial symptoms: Limb-Onset ALS, and Bulbar-Onset ALS. Over time, ALS often progresses to involve both limb and bulbar regions, causing widespread motor function issues. The…